Advances in Enzymology and Related Areas of Molecular by Alton Meister

By Alton Meister

Evolution of Glutathione Metabolism (R. Fahey & A. Sundquist).

Covalent Inhibitors of the Gelation of Sickle cellphone Hemoglobin and Their results on functionality (J. Manning).

Structural foundation for Catalysis through Tryptophan Synthase (E. Miles).

constitution and Mechanism of F0F1-Type ATP Synthases and ATPases (H. Penefsky & R. Cross).

Novel facets of the Biochemistry of the Molybdenum Cofactor (K. Rajagopalan).

Ovothiols: organic and Chemical views (B. Shapiro & P. Hopkins).

N?5-(1-Carboxyethyl)Ornithine and comparable [N-Carboxyalkyl]-Amino Acids: constitution, Biosynthesis, and serve as (J. Thompson & S. Miller).


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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 64

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SUNDQUIST a portion of the rat mu family GST sequence and a portion of the mammalian thioredoxidglutaredoxin has been noted (146). However, the region does not correspond to the highly conserved region shown in Fig. 5B and there is little similarity to GSTs other than those of the mu family. Still, the overall three-dimensional structure and organization could be retained even though the primary structure has changed to the point where homology is no longer recognizable. If so, only x-ray crystallographic studies are likely to resolve the issue.

113. 114. 115. 116. 117. 118. 119. 120. 121. 122. ROBERT C. FAHEY AND ALPRED R. SUNDQUIST li, 1. , Biochim. Biophys. Acta, 350, 141-150 (1974). ma,A. and Tezcan, E. , Biochem. , 25, 81-91 (1981). Latta, K. and Augusteyn, R. , Exp. , 39, 343-354 (1984). Muhammed, S. and-Tezcan. E. , Doga. Seri C, 5, 115-118 (1981). Ng. C. and Shichi. , Exp. Eye Res.. 43,477-489 (1986). Ramos-Martinez, J. , Rodriguez BartolomC. , Comp. Biochem. Physiol. B, 758,689492 (1983). Ramos-Mertinez, J. I. and Rodriguez Toms, A.

In those eukaryotes capable of photosynthesis, another source of the genes for some of these enzymes could have been the endosymbiont giving rise to chloroplasts, that is, a relative of the cyanobacteria. The latter route is the most plausible pathway by which the gene for dehydroascorbate reductase was introduced into plants. In eukaryotes lipid peroxidation appears to be a more important process than in prokaryotes, and the evolution of GST supergene families of enzymes in eukaryotes was probably driven, in part, by the need to limit the damaging effects of this process.

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